منابع مشابه
Gene dosage and gene duplicability.
The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more paralogs than haplosufficient genes in the human genome. However, the pr...
متن کاملGene Complexity and Gene Duplicability
Eukaryotic genes are on average more complex than prokaryotic genes in terms of expression regulation, protein length, and protein-domain structure [1-5]. Eukaryotes are also known to have a higher rate of gene duplication than prokaryotes do [6, 7]. Because gene duplication is the primary source of new genes [], the average gene complexity in a genome may have been increased by gene duplicatio...
متن کاملGene dosage balance in cellular pathways: implications for dominance and gene duplicability.
THE gene dosage balance hypothesis (GDBH) profrom the selective cost of their overproduction. Thus, poses, in a narrow sense, that stoichiometric imbalsome genes encoding interacting pairs should remain ances in macromolecular complexes can be a source of as single copies (case of B) or otherwise undergo codominant phenotypes. Gene dosage balance in such duplication with genes encoding their pa...
متن کاملExpression of Concern: Protein Under-Wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability
A fundamental issue in molecular evolution is how to identify the evolutionary forces that determine the fate of duplicated genes. The dosage balance hypothesis has been invoked to explain gene duplication patterns at the genomic level under the premise that a dosage imbalance among protein-complex subunits or interacting partners is often deleterious. Here we examine this hypothesis by investi...
متن کاملOrganismal complexity, protein complexity, and gene duplicability.
Although the evolutionary significance of gene duplication has long been recognized, it remains unclear what determines gene duplicability. We find protein complexity to be an important determinant because the proportion of unduplicated genes (P) increases with the number of subunits in a protein. However, P is high (>or=65%) for both monomers and multimers in yeast, but <or=30% in human except...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics
سال: 2008
ISSN: 1943-2631
DOI: 10.1534/genetics.108.090936